Multicellular organisms (animals, plants, humans) all have the ability to methylate the cytosine base in their DNA. This process, a type of epigenetic modification, plays an important role in ...

Cancer continues to be one of the world's top causes of death, partly because of delayed discovery of the disease. But according to a recently released study, a simple blood test may be able to ...

All the cells in an organism have the exact same genetic sequence. What differs across cell types is their epigenetics—meticulously placed chemical tags that influence which genes are expressed in ...

This study presents a large, systematically curated catalog of non-canonical open reading frames (ncORFs) in human and mouse by reanalyzing nearly 400 Ribo-seq datasets using a standardized pipeline; ...

Scientists at The Hospital for Sick Children (SickKids) have revealed a previously overlooked layer of genetic variation that could help explain why people experience disease differently, and why some ...

This study presents a valuable tool named TSvelo, a computational framework for RNA velocity inference that models transcriptional regulation and gene-specific splicing. The evidence supporting the ...