In a two-color experiment (panel a in the figure) DNA from individuals of the same species or different tissue from a single individual (e.g., normal and diseased cells) is extracted and ...

In each type of cell, like a muscle cell or a skin cell, different genes are expressed (turned on) or silenced (turned off). If the cells that are turned on mutate, they could—depending on what role ...

Two of the critical issues that arise when examining DNA microarray data are (1) determination of which genes best discriminate among the different types of tissue, and (2) characterization of ...

For most researchers DNA microarrays are synonymous with high-throughput gene expression analysis. But they also are invaluable genotyping tools. Now that the International HapMap Project (see article ...

Comparative genomic hybridization (CGH) was developed to identify pathogenic DNA copy-number changes (e.g., duplications, deletions) on a genome-wide scale, and to map these changes to genomic ...

BUFFALO, N.Y. -- A multidisciplinary team of pharmaceutics and computer-science researchers at the University at Buffalo, one of very few teams in the nation applying DNA microarray technology in ...